In nucleic acid detection, nucleic acid hybridization technology is the "sharp eye" for identifying specific target sequences. Its core step—high-temperature denaturation (usually 95℃)—is the key to unlocking double-stranded DNA, releasing single strands for precise pairing. However, this step poses the following severe "heat tests" for traditional fluorescent encoded microspheres:
- Fluorescence leakage: The high temperature of 95℃ can cause microspheres to rupture, leading$to the leakage of fluorescent dye molecules.
- Stability failure: It results in probe detachment or reduced hybridization efficiency.
💪 Beadstar Bio's "Heat Resistance Revolution"
Beadstar Bio has launched magnetic fluorascent encoded microspheres for nucleic acid detection, which are resistant to high temperatures and provide a reliable "heat-resistant cornerstone" for multiplex nucleic acid detection.
- Thermal stability of microspheres (taking 7-plex dual-fluorescent encoded microspheres as an example): After exposure to 95℃ for 5 minutes, the fluorescent encoding positions show no deviation, ensuring accurate identification in multiplex detection.
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